Mucosal-associated invariant T cells and disease
نویسندگان
چکیده
منابع مشابه
mucosal-associated invariant T cells
© 2008 Huang et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1201-1211 www.jem.org/cgi/doi/ 1201 10.1084/jem.20072579 Mucosal-associated invariant T cells (MAITs) are a unique “ innate ” T cell population that expresses an invariant mV 19 TCR in mice and the homologous hV 7.2 in humans ( 1 ). With the exception of preferential localization in the intestine, MAIT cell...
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Background and Aims: Mucosal-associated invariant T (MAIT) cells are striking lymphocyte population in the blood and their importance in immune responses is growing fast. The current study was conducted to evaluate leptin hormone effects on MAIT cell functions. Materials and Methods: Five healthy male donors in ages of 22-30 years were selected and peripheral blood mononuclear cells (PBMCs) ...
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A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings show the presence in uninfected individuals of mucosal associated invariant T (MAIT) cells that mount broad spectrum immune responses against a ...
متن کاملMucosal-associated invariant T cells in clinical diseases.
UNLABELLED Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial infection via vitamin metabolites. The discovery of MAIT cells in the past two decades and the recent discovery of MR1 ligands has opened a new field and potential area for cellular immunotherapy using these unique cells. Their evolutionary conservation in mammals underscore their biological ...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2019
ISSN: 1474-1733,1474-1741
DOI: 10.1038/s41577-019-0191-y